Cortellis Drug Discovery Intelligence
Drug Discovery Intelligence — The flagship preclinical drug discovery platform integrating biology, chemistry, and pharmacology data
Cortellis Drug Discovery Intelligence (CDDI) is Clarivate's flagship preclinical drug discovery intelligence platform, building on the legacy of the Integrity database (30+ years of heritage), officially relaunched in 2019. Built by scientists for scientists, the platform is manually curated and validated by PhD- and MD-level research professionals with 25+ years of experience, delivering the most comprehensive, in-depth, and accurate preclinical R&D intelligence source to help researchers avoid late-stage failures and bring drugs to clinical use faster.
85% of the world's top 20 pharmaceutical companies trust CDDI as their core data foundation for target-to-candidate research across all therapeutic areas. The platform is built on a cloud SaaS architecture (AWS), supports 12+ domain-specific APIs, and integrates OFF-X safety data with MetaCore systems biology analytics.
Cortellis Drug Discovery Intelligence — The flagship preclinical drug discovery platform integrating biology, chemistry, and pharmacology data
Data Coverage
Drugs & Biologics
A single database providing more early-stage drug discovery data than any other source
Genes & Targets
Granular target and mechanism of action (MOA) information linked to related diseases and therapies, with OFF-X expanding to 49,000+
Biomarkers
The most diverse preclinical and clinical biomarker data linked to related diseases and therapies
Pharmacology Data Points
Access key information from in vitro and in vivo pharmacological assays and pharmacokinetic studies
Patents
Drug patent information covering 7 major patent offices, linked to related diseases and therapies
Experimental Models
Data unique to drug development and pharma, including organ-on-chip and organoid coverage (2024 new feature)
Literature & Publications
From 1,500+ journals and 160+ scientific conferences, fully leveraging R&D data from a scientific perspective
Diseases Covered
Across 30 therapeutic areas, expandable to 6,500+ diseases with OFF-X
Core Features
Integrated Biology, Chemistry & Pharmacology Data
A single platform updated daily, consolidating preclinical information into one flexible resource. Covering data from first public disclosure to commercial launch, with 20+ granular filter criteria
Target Identification & Validation
44,000+ genes and targets with disease association scores. Target prioritization tools allow uploading custom gene lists. Pathway maps overlay known drug targets, disease relationships, and adverse events
Chemical Structure Search
540,000+ bioactive compounds supporting exact match, similarity, and substructure searches. Enables structure-activity relationship (SAR) analysis and QSAR building from literature and patents
Pharmacology & Pharmacokinetics Data
2,800,000+ pharmacology data points covering key PK parameters: AUC, half-life, clearance, volume of distribution, and bioavailability. Supports drug candidate comparative analysis
Biomarker Intelligence
43,000+ biomarkers with 2,300,000+ usage records. Dedicated module supporting all stages of drug development, with pathway maps to explore biomarker biological plausibility
Pathway Maps (MetaCore Integration)
1,600+ exclusively curated pathway maps and 1,700,000+ molecular interactions, visualizing cell signaling pathways and supporting RNA-seq, metabolomics, and proteomics data analysis
OFF-X Safety Integration
Approximately 3 million curated safety alerts covering 15,000+ targets, with disease-specific signaling pathway visualization overlaying safety data, and 80% faster loading times
VeriSIM Life Translational Index
AI-driven prediction of compound safety and efficacy insights, capable of predicting bioavailability, clearance, clinical toxicity, and first-in-human dose
API & Data Integration
12+ domain-specific APIs via Cortellis Labs, including Drug Design, Targets, Biomarkers, Analytics, and Data Feed APIs, supporting JSON/XML output and Python libraries
CDDI Dashboard — Drug highest stage distribution, biological process analysis, gene variation and molecular function statistics
CDDI Drug Discovery Intelligence — One-stop access to biology, chemistry, and pharmacology data covering 560K+ drugs and biologics
Therapeutic Area Coverage
Covering over 2,600+ diseases and 30 therapeutic areas, including:
Oncology
Extensive target and compound data, combination therapy pathway analysis
Immunology
Immune pathway maps, immunotherapy development biomarker data
CNS
Brain target validation, blood-brain barrier permeability, neurodegenerative disease reviews
Cardiovascular
Cardiac safety targets, mechanism of action exploration
Respiratory
Pulmonary drug target landscape, inhaled drug development support
Vaccines
Pathogen target analysis, immunogenicity biomarkers
Endocrinology
Metabolic pathway analysis, diabetes drug pipeline monitoring
Rare Diseases
Covering 6,500+ diseases (including rare/orphan diseases)
Drug Discovery Lifecycle Positioning
| Stage | CDDI Capabilities |
|---|---|
| Target Exploration | Gene-disease associations (230K+), pathway analysis (MetaCore), systems biology |
| Target Validation | Disease association scores, MOA data, pathway maps, safety signals (OFF-X) |
| Lead Identification | Bioactive compound database (540K+), chemical structure search |
| Lead Optimization | SAR analysis, QSAR building, structure-activity comparison, synthesis schemes |
| Preclinical ADME/PK | In vivo and in vitro PK parameters, experimental models (152K+) |
| Preclinical Safety | OFF-X integration (~3 million safety alerts), VeriSIM Life AI predictions |
| Biomarker Discovery | Preclinical/clinical biomarker data (43K+), biomarker module |
| Clinical Translation | Clinical PK data, translational biomarkers, first-in-human dose prediction |
Key Differentiators
Integrated Platform
Biology + Chemistry + Pharmacology in one — competitors (SciFinder, Reaxys) focus solely on chemistry
Data Heritage & Expert Curation
Built on 30+ years of curated data from the Integrity database, manually curated and validated by PhD/MD-level scientists (25+ years of experience)
Pathway Analysis & Ecosystem
MetaCore integration (1,600+ maps, 1.7M+ interactions) — not offered by chemistry-focused competitors. Seamless integration across 10+ Cortellis modules with single sign-on
Safety Integration & AI Prediction
Full OFF-X integration (~3 million safety alerts) — a unique combination; VeriSIM Life Translational Index provides early safety/efficacy prediction
CDDI Metabolic Pathway Visualization — Metronidazole biotransformation pathway and enzyme reaction analysis
Industries & Users
| Industry | Applications |
|---|---|
| Large Pharma | End-to-end drug discovery intelligence; 85% of the global top 20 pharma companies use CDDI |
| Biotech Companies | Target validation, lead optimization, preclinical benchmarking for emerging biotech |
| Contract Research Organizations | Preclinical data analysis, safety assessment, competitive benchmarking for client projects |
| Academic Institutions | Basic research, target exploration, data-driven R&D education |
| Government Agencies | U.S. government OFF-X + CDDI biomarker module contract; R&D trend analysis |
| VC / Private Equity | Pipeline asset evaluation, target landscape analysis to support investment decisions |
CDDI Chemical Structure Search — Molecular drawing tool supporting exact match, similarity, and substructure searches
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